The Earth’s orbital space environment constitutes a finite resource that is being used by an increasing number of States, international intergovernmental organizations, and non-governmental entities. The proliferation of space debris, the radiation belts presenting a real hazard to satellites and astronauts, the increasing complexity of space operations, the emergence of large constellations, and the increased risks of collision and interference with the operation of space objects may affect the long-term sustainability of space activities in a negative way. Addressing these developments and risks requires efficient regulatory frameworks and international cooperation by States and international intergovernmental organizations to avoid harm to the space environment and the safety of space operations. Moreover, outer space activities are essential tools for realizing the achievement of Sustainable Development Goals. The IASL Outer Space Sustainability Center of Excellence is designed to properly address regulatory aspects of ensuring the long-term sustainability of outer space activities.